The direct cause of suffering for each and every instance of suffering is entirely produced by the mind. I have no problem with that statement. The material cause of suffering is the thing that "stuff" which turns into that mind (the actual physical material that becomes brain, which produces mind or, if you don't believe mind is an emergent property of the brain's activities, then, the mental stuff that turns into current mind). So, this refers to egg and sperm, generally (for most sentient beings). These are produced externally; they are not at all influenced by mental fabrications. No mind has been formed yet so no such fabrications can even exist….