Wow, I never thought about this. I'm in Menopause, haven't had a period since Last March, and during R1, well when I stopped R1 and stopped the drops was about the same time I started spotting and then a full blown period. Called my doc but it never accured to me it was from the HCG so I didn't even mention it to her. (My GYN Doc), I just didn't know if I needed to adjust my HRT meds or not. Now it all makes sense. I'm about to start R2 soon so I will know if this happens again and not freak out about it.