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**tipokotap** · 08-11-2009, 11:42 PM

Found it at: http://www.medicine.org/profiles/blo...ene-discovered.

Twenty-five years ago in the town of Limone Sugata, Italy, a man went to his doctor for a check up. His doctor discovered that he had very high cholesterol levels, but no signs of heart disease. The same was true of his entire family and many people in his town, who were descended from one couple and shared a unique gene. It appeared that no matter what these families ate, no matter how high their cholesterol levels, it never caused heart disease.

It was discovered that this incredible ability was due to a mutated gene. The first study on the gene (named Apo A1-Milano), showed it might protect against heart disease in an unusual way by making an incredibly powerful form of HDL, or good cholesterol, that pulls fat out of the vessels and takes it to the liver to be eliminated from the body.

Working at the Cleveland Clinic and in Los Angeles at the Cedars Sinai Medical Center, Dr. Steven Nissen is studying how this gene could provide a cure for heart disease for the rest of us.

Researchers have created a synthetic form of the new gene's powerful HDL that significantly reduces plaque, potentially paving the way for a one-time shot that could cure coronary heart disease.

08-11-2009, 11:42 PM	#5
tipokotap Join Date Oct 2005 Posts 735 Senior Member	Found it at: http://www.medicine.org/profiles/blo...ene-discovered. Twenty-five years ago in the town of Limone Sugata, Italy, a man went to his doctor for a check up. His doctor discovered that he had very high cholesterol levels, but no signs of heart disease. The same was true of his entire family and many people in his town, who were descended from one couple and shared a unique gene. It appeared that no matter what these families ate, no matter how high their cholesterol levels, it never caused heart disease. It was discovered that this incredible ability was due to a mutated gene. The first study on the gene (named Apo A1-Milano), showed it might protect against heart disease in an unusual way by making an incredibly powerful form of HDL, or good cholesterol, that pulls fat out of the vessels and takes it to the liver to be eliminated from the body. Working at the Cleveland Clinic and in Los Angeles at the Cedars Sinai Medical Center, Dr. Steven Nissen is studying how this gene could provide a cure for heart disease for the rest of us. Researchers have created a synthetic form of the new gene's powerful HDL that significantly reduces plaque, potentially paving the way for a one-time shot that could cure coronary heart disease.
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