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Now back to the original issue. Why is the meat of donkey haram? Because Allah prohibited eating the meat of donkey and his Prophet (s.a.w) conveyed this message to us. The "reason" for any command/prohibition in Islam is pure Divine and there can be no questioning about it. However, one might wonder the wisdom behind this and that prohibition or command.. There could be many that we know, or they maybe the cases where we have not given any knowledge of. For example, wisdom behind the prohibition of the pork could be that it is dirty, however, this is not the reason for prohibition. The reason is purely command of Allah. That's why even if someone disinfects and sanitizes the pork thoroughly, still it does NOT become halal.

Imam Abu Hanifa and Imam Malik along the text of ahadith, they derive the proof from the verse Nahl-16/8: "And [He created] the horses, mules and donkeys for you to ride and [as] adornment. And He creates that which you do not know." Because these animals have been created for different purpose i.e ride and adornment, hence eating them is not allowed. So, similar prohibition of eating their flesh goes for horses and mules.