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**offinoNem** · 08-22-2009, 11:27 PM

****, it even has its own Wikipedia entry

http://en.wikipedia.org/wiki/Lead_time_bias

Suppose you are correct in positing that lead time bias is at work, can you demonstrate that lead time bias is responsible for all the difference in death rate?

Note also, lead time bias can only change the statistics for the period of time the patient is still alive. Once the patient dies, the lead time no longer matters. Unless the study is conducted over a period of time that is not long compared to the lead time differential, there is little effect on the result.

08-22-2009, 11:27 PM	#23
offinoNem Join Date Oct 2005 Posts 445 Senior Member	***, it even has its own Wikipedia entry http://en.wikipedia.org/wiki/Lead_time_bias Suppose you are correct in positing that lead time bias is at work, can you demonstrate that lead time bias is responsible for all the difference in death rate? Note also, lead time bias can only change the statistics for the period of time the patient is still alive*. Once the patient dies, the lead time no longer matters. Unless the study is conducted over a period of time that is not long compared to the lead time differential, there is little effect on the result.
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