[dumadegg]

So everyone says it is eradicated you are showing your lack of microbiological perspective

Although patients remain infectious until the last scabs fall off, the large amounts of virus shed from the skin are not highly infectious. kill rate ~1%... not 100% nor 30%....

I am not going to give you a course in microbiology..... of course you understand scientific terminology is not easily understood by lay

Just as an exercise

Where do you think bugs, in this case Variola sp came from ?
Smallpox, which is believed to have originated over 3,000 years ago in India or Egypt, do you think it just popped into existence 3,000 years ago ??


or was that when RECORDS occurred

weird people!

[naturaherbal]

you are showing your lack of microbiological perspective


kill rate ~1%... not 100% nor 30%....

I am not going to give you a course in microbiology..... of course you understand scientific terminology is not easily understood by lay

Just as an exercise

Where do you think bugs, in this case Variola sp came from ?

do you think it just popped into existence 3,000 years ago ??


or was that when RECORDS occurred

weird people!

I suppose you think that canine pavo was only recorded in the 70s but in fact existed for all time ..

[machpamb]

Boy, you people must be so bored if you are going to waste time engaging Zarky. He's a time-waster and an oxygen bandit.

Woof! Woof! Grrr!

[Prererularl]

Zarkov thinks we still have smallpox. Once again he is correct and real scientists are wrong

Where is that water powered land rover, I need to get out of here.

[DownloadADOBEsoftware]

Scientists studying flu vaccines have identified ways to overcome an obstacle called "original antigenic sin," which can impair immune responses to new flu strains.

Original antigenic sin (OAS) is a situation where the immune system is fighting with obsolete weapons and has trouble adapting. After encountering one viral strain, and then a new one that is related to the first, the immune system can respond by making antibodies against the first strain, resulting in a less effective defense.

The findings could be important when vaccinating individuals with weaker immune systems, such as people with chronic infections, small children or the elderly, the authors write. The influenza virus has become so widespread because it can infect a wide range of hosts such as pigs and birds, and because its genome is flexible, Jacob says. Influenza strains change their DNA in two ways.

Antigenic drift occurs as a strain accumulates small mutations, which can help it escape from the host’s immune system. Antigenic shift occurs when two strains, possibly from different host species, swap DNA.

"Original antigenic sin is really a reflection of the agility of the influenza virus," he says. "OAS becomes a factor when the new circulating strain is a ‘drifted’ version of what came before. The old antibodies can’t neutralize the new virus, and that helps the new virus survive."

Read more at: http://medicalxpress.com/news/2012-0...ccine.html#jCp Use your big guns on the masses
and antigenic responses to a related maybe more virulent strain become compromised
and SUDDENLY everyone is at risk

Playing with fire earthlings

[SnareeWer]

un edited version.

Immunology Research - Proteins, Antibodies, ELISA kits, Bulks & Vials, Quality Guaranteed - www.sinobiological.com

Original antigenic sin (OAS) is a situation where the immune system is fighting with obsolete weapons and has trouble adapting. After encountering one viral strain, and then a new one that is related to the first, the immune system can respond by making antibodies against the first strain, resulting in a less effective defense.

Researchers at Emory Vaccine Center have demonstrated in experiments with mice that OAS can be overcome by using a vaccine additive called an adjuvant, or by repeated immunization with the second viral strain. The results were published this week in Proceedings of the National Academy of Sciences.

The first author of the paper is postdoctoral fellow Jin Hyang Kim, who now works on influenza at the Centers for Disease Control and Prevention. The senior author is Joshy Jacob, PhD, associate professor of microbiology and immunology at Emory University School of Medicine.

The findings could be important when vaccinating individuals with weaker immune systems, such as people with chronic infections, small children or the elderly, the authors write.

The influenza virus has become so widespread because it can infect a wide range of hosts such as pigs and birds, and because its genome is flexible, Jacob says.

Influenza strains change their DNA in two ways. Antigenic drift occurs as a strain accumulates small mutations, which can help it escape from the host’s immune system. Antigenic shift occurs when two strains, possibly from different host species, swap DNA.

"Original antigenic sin is really a reflection of the agility of the influenza virus," he says. "OAS becomes a factor when the new circulating strain is a ‘drifted’ version of what came before. The old antibodies can’t neutralize the new virus, and that helps the new virus survive."

In a Journal of Immunology paper published in 2009, Jin and Jacob showed that OAS could impair the immune responses of mice exposed to two well-studied H1N1 flu strains: PR8, from 1934, and FM1, from 1947.

If mice are immunized first with inactivated PR8 virus and a month later FM1, and then exposed to live FM1, the lungs of the mice had higher viral levels than those that weren’t immunized first with PR8. This effect was even stronger after sublethal infection with live virus, rather than vaccination with inactivated virus.

In the new PNAS paper, Jin and colleagues demonstrated that combining the FM1 immunization with an adjuvant allows the mice to respond better to the live virus. The adjuvant is a squalene oil-in-water emulsion. Squalene is a vaccine additive licensed in European countries since the 1990s, but not approved for use in the United States. Surprisingly, the adjuvant could also improve immune responses when combined with the initial PR8 immunization.

"It appears that the adjuvant is making the immune responses to the first viral strain broader, so that a wider range of antibody-producing cells are able to respond to the second strain," Jacob says.

The handicap of the twice-immunized mice against the second virus could also be overcome by a booster shot against the second virus. The authors write:

"Collectively, our findings imply that OAS could potentially be prevented in the naïve human population, especially children, by administering adjuvants with the first influenza vaccine. Alternatively, in the older population with prior influenza virus exposure or vaccinations, original antigenic sin can be minimized by using adjuvants."

[bestbyV]

Long live the selective quote. Haven't lost your touch for it, Zarky.

[illetrygrargo]

Thank you Gentleman, but I am still not convinced that immunization by humans is the best answer. My father was against immunization and he wouldn’t allow me to be immunized, but I was once at school. I am still very fit and healthy at 68 years of age. I spent my working life as a surveyor and now as a prospector. I played my first eight holes of golf with a group of pensioners today and a lady accused me of having played before ! I had no serious illness as a child or adult. I have sex about once a week with my 66 year old very sexy Lady : ) . Most of my mates are dead from self inflicted illness caused by alcohol, tobacco, bad diet, junk food, obesity, laziness etc.

My first five children all lived in Darwin city and were all fully immunized. They got the flu every year and colds and fevers and other weird illnesses. It was a nightmare at times. They were only breast fed for a few weeks and their diet was not good.

My second two children with my second wife had no immunizations and they are by far the healthiest of them all. My wife studied the subject thoroughly for 6 months before she got pregnant. She never used the pill, but I used condoms. She breast fed my son for two and a half years and my daughter for 2 years. We lived in a jungle that always had mosquitoes, sand flies and various other biting insects. (Natural immunization ?)

I grew various vegetables and fruit trees and made fresh bread twice a week from organic wheat that I ground in an electric stone mill. We drank untreated water from a well in the ground. I am a keen fisherman and we ate fish at least twice a week. We had our own free range chickens, ducks and geese for eggs and meat. We also had two Jack Russel dogs and they are now 15 and 16 years of age and they are still fit and healthy, except for their teeth.

These two children had a far better diet and exercise regime than my first family. My son is now 32 and a self employed L.A.M.E. He is very fit and healthy and has never suffered any illness apart from a couple of mild colds. My daughter is 28 and an accountant with an Airline. She plays touch rugby etc. She has never suffered any serious illness apart from a couple of mild colds.

Immunization is probably the best answer for most people living in cities, but I would still not recommend it to anyone, despite your learned advice ! “You are what you eat etc…” IMNSHO.

[mikeydesignzinc]

If you had caught polio as a child, and many of your generation did, you might be singing a different tune.

[Grewlybreekly]

My first five children all lived in Darwin city and were all fully immunized. They got the flu every year and colds and fevers and other weird illnesses. It was a nightmare at times. They were only breast fed for a few weeks and their diet was not good.

My second two children with my second wife had no immunizations and they are by far the healthiest of them all. My wife studied the subject thoroughly for 6 months before she got pregnant. She never used the pill, but I used condoms. She breast fed my son for two and a half years and my daughter for 2 years. We lived in a jungle that always had mosquitoes, sand flies and various other biting insects. (Natural immunization ?)
----------------
It is interesting that you are drawing comparisons between two groups that have different genes and enviromental conditions, but only ever blame one factor.

[Jorcelirl]

Confirmation bias. AuDigga falls for all the good fallacies.

[Infellgedq]

so you werent completely shit at golfd

[NickGrass]

If you had caught polio as a child, and many of your generation did, you might be singing a different tune.

But he was vaccinated, when he went to school, and apparently, not autistic (what are the chances?).

Frankly, my reading of his story leads me to believe he wasn't in a happy place, during the first marriage, which coloured his experiences. Both sets of children got colds (which have nothing to do with general childhood vaccinations), yet in the first set it was some big drama and the second just "mild colds".

[illiniastibly]

Well he lives in Darwin never going to be happy

[teergoBissono]

OAS can be overcome by using a vaccine additive called an adjuvant, or by repeated immunization with the second viral strain. Unfortunately often the second viral strain is a stealth bomber

But yes, kill the patient is an effective answer

I have presented many reasons why vaccination is in general a procedure with maybe bad future consequences.... as is ALL intra-body additions..... eventually the worm turns

What you do is your business..... but think again when you blame the people who do not agree with you.

[Britiobby]

Zarkov, that is plainly a bunch if baloney. Show the evidence for these relative risks, not individual cases, but actual risks compared.

[Smabeabumjess]

Zarkov, you haven't presented any reasons, except the USA invaded Iraq, therefore vaccines are bad.

[Goooooblin]

Thank you Gentleman, but I am still not convinced that immunization by humans is the best answer. My father was against immunization and he wouldn’t allow me to be immunized, but I was once at school. I am still very fit and healthy at 68 years of age...

Well, obviously the vaccinations are responsible! (Note the post hoc fallacy.)

One thing that bugs me about people opposed to vaccination is that so many of them promote techniques which are essentially identical to vaccination : pox parties. They deliberately expose their children to the disease so that the children's immune systems get a taste of the disease and develop antibodies. Yet apparently doing this in a controlled manner in the form of a vaccine is somehow evil. And before AuDigga or others complain that the vaccine is injected, this was essentially the way variolation for smallpox worked - scratch a child's skin, then insert a piece of infected scab.

[atmowasia]

"so many of them promote techniques which are essentially identical to vaccination : pox parties"

Before the rubella vaccine was available when I was a kid, when any local child got German measles all the kids who hadn't had it were sent to visit, particularly the girls. Rubella in children is, for the most part, a mild illness but it has horrifying effects on babies in the womb. The vaccine today makes such visits unnecessary.

[MaugleeRobins]

We never had pox parties- every kid in my class got it anyway (And right before the Christmas holidays too!)