Jayy - Yeah I gained 30 pounds while on Paxil & just continued to gain while on Effexor. I SO wish I was in a better place at that time to have made a clearer decision about being on these particular anti-depressants. In talking to my doctor recently about the PMDD... apparently Paxil & Effexor are the "big guns" of the anti-depressant world! I know I was in a BAD BAD place dealing with having been wrongly accused in my job & everything else horrible you could imagine. This unfortunately lasted about 5 years with the first 3 being the worst. I am better off now since everything is over but trying to loose the weight I gained is almost impossible! One little mess up & things just creep back up!