have you considered talking to your doctor about metformin for the leptin resistance? Holtorff Med has a paper on the treatment (I'm not associated with them, just read their articles) they use symlin and byetta but those both work like metformin [URL="http://www.holtorfmed.com/index.php?section=downloads&file_id=19"]http://www.holtorfmed.com/index.php?section=downloads&file_id=19[/URL