[ThzinChang]

Mechanism discovered for health benefit of green tea, new approach to autoimmune disease

June 2, 2011
One of the beneficial compounds found in green tea has a powerful ability to increase the number of "regulatory T cells" that play a key role in immune function and suppression of autoimmune disease, according to new research in the Linus Pauling Institute at Oregon State University.


This may be one of the underlying mechanisms for the health benefits of green tea, which has attracted wide interest for its ability to help control inflammation, improve immune function and prevent cancer.
Pharmaceutical drugs are available that perform similar roles and have been the subject of much research, scientists say, but they have problems with toxicity. A natural food product might provide a long-term, sustainable way to accomplish this same goal without toxicity, researchers said.
"This appears to be a natural, plant-derived compound that can affect the number of regulatory T cells, and in the process improve immune function," said Emily Ho, an LPI principal investigator and associate professor in the OSU Department of Nutrition and Exercise Sciences.
"When fully understood, this could provide an easy and safe way to help control autoimmune problems and address various diseases," Ho said.
The findings have been published in Immunology Letters, a professional journal.
There are many types of cells that have different roles in the immune system, which is a delicate balancing act of attacking unwanted invaders without damaging normal cells. In autoimmune diseases, which can range from simple allergies to juvenile diabetes or even terminal conditions such as Lou Gehrig's disease, this process goes awry and the body mistakenly attacks itself.
Some cells exist primarily to help control that problem and dampen or "turn off" the immune system, including regulatory T cells. The number and proper function of those regulatory T cells, in turn, is regulated by other biological processes such as transcription factors and DNA methylation.
In this study, OSU scientists did experiments with a compound in green tea, a polyphenol called EGCG, which is believed to be responsible for much of its health benefits and has both anti-inflammatory and anti-cancer characteristics. They found it could cause a higher production of regulatory T cells. Its effects were not as potent as some of those produced by prescription drugs, but it also had few concerns about long-term use or toxicity.
"EGCG may have health benefits through an epigenetic mechanism, meaning we aren't changing the underlying DNA codes, but just influencing what gets expressed, what cells get turned on," Ho said. "And we may be able to do this with a simple, whole-food approach."
Laboratory studies done with mice, Ho said, showed that treatment with EGCG significantly increased the numbers and frequencies of regulatory T cells found in spleen and lymph notes, and in the process helped to control the immune response.
"Epigenetic regulation can be potentially exploited in generating suppressive regulatory T cells for therapeutic purposes, and is of significant clinical importance for the suppression of autoimmune diseases," the researchers said in their study.
Provided by Oregon State University

[swissloveone]

Thanks for sharing such a great information about green tea. It is really very informative and useful for me. I really like your post.

[Vegeinvalge]

The benefits of green tea are really mind blowing and thanks for the share sure i am going to share in social accounts which will help people to know the health value of green tea.

[Hetgvwic]

Hi Barbara,
Great threat on green tea and like to add some more benefits of green tea.
Green tea is great antioxidant and helps in losing weight by burning fat and regulating metabolism. Green tea is great for hair, nails and skin. Green tea reduce the risk of diabetes, cancer, cardiovascular disease, tooth decay and influenza.

[AngelBee]

OOH this is one of the good and detailed post I ever read on benefits of green tea, I am dam sure that you have done really good research on this valuable post. And I want to say that this will really helpful for many people's.

[piramirra]

Green tea is really useful for weight loss. It contains high amount of caffeine that is useful for burning fat. But don't overuse green tea because it may be harmful for your muscles and liver function. Using green tea in a limit in long run is useful for being fit.