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Old 06-23-2010, 02:12 AM   #1
Gypejeva

Join Date
Oct 2005
Posts
442
Senior Member
Default A five year timeline for tissue engineered livers
From the Telegraph: a new methodology "could be used to recycle thousands
of donated organs which are at present considered too old or damaged for
transplantation. ... Many livers have to be discarded because they are too
old or too damaged to be of any use.
The new technique works by effectively chemically stripping the old liver
down too its basic 'scaffold' or exoskeleton in a process of called
'decellularisation'. Onto this frame of connective tissue and blood
vessels, they then regrow the new liver using stem cells from the patient.
Stem cells from embryos could also be used. The effectively brand new liver
is then transplanted back into the patient. At the moment the technique
will require donor organs but it is hoped that eventually pig's livers or
artificial scaffolds can be used instead - effectively avoiding donors
altogether. ... This scaffold retains for the most part the detailed
microarchitecture of the liver, including essential structures such as the
blood vessels. We take advantage of this remaining structure to repopulate
the scaffold with liver cells to recreate a functional liver. As we have
shown this re-engineered liver performs the most essential liver functions
in the lab and can be transplanted into rats and stays intact, with the
cells able to survive."
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