[papadopul]

The Brown Basis Institute of Molecular Medicine for preventing Human Diseases The Laboratory for Developmental Biology Telephone 713.500.2452; fax 713.500.2424 transgenic@uth.tmc.edu Ron A. Wetsel, Ph.D.; Professor and Director Eva M. Zsigmond, Ph.D.; Associate Professor and Associate Director Aleksey Domozhirov; Supervisor blastocyst microinjectionThe Laboratory for Developmental Biology was founded to simply help boffins at the Institute of Molecular Medicine and the University of Texas conduct research that needs the creation of transgenic and knock-out animal types of individual conditions. Genetically-altered animals, named transgenic and "knock-out" animals, represent priceless types of human genetic disorders. In to be able to examine the position that particular gene services and products play in the pathogenesis of various illnesses these animals, prospect genes are inserted or removed. Throughout the last five decades, new, transgenic and knock-out mouse lines have been produced over five hundred by the Laboratory for Developmental Biology for boffins from the Brown Foundation Institute of Molecular Medicine, the University of Texas, Baylor College of Medicine and MD Anderson Cancer Center. Some of your pet types produced as of this Core Facility were crucial in the development of new genes which have significant functions in the development of asthma, cardiovascular disease and cancer, simply to name several. By working with and helping boffins to enhance their study, the Core Facility is becoming an intrinsic and respected element of the University. GFP miceRecently, the solutions of the Laboratory for Developmental Biology have broadened to incorporate a Cell Research Core Facility. This is actually the only service in the Texas Clinic that provides researchers technical and rational support in stem cell research. Mouse base lines recently produced in the laboratory can be found to researchers to be able to combine this innovative new technology to their own study to make use of in their tests. Along with giving technical and rational help other boffins, the Laboratory for Developmental Biology also performs initial study in stem cell therapy. transgenic microinjectionThe laboratory's current achievements range from the derivation of new, impressive mouse stem cells and the genetic modification of those cells to produce a green light. The altered, excellent stem cells might be creatively adopted when re-implanted in to the body and therefore an invaluable tool is represented by them for learning the procedure by which stem cells replenish cells and organs that have now been broken by illness. The Laboratory's future research programs range from the genetic engineering of the stem cells to avoid immune rejection subsequent transplantation into a different patient, difference of the stem cells into different cell types for transplantation research, and the use of the data and experience which was acquired by operating with the mouse stem cells to research with human stem cells.